Working with solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our investigate passions incorporate:
It absolutely was only while in the nineteen nineties however, when nanotechnology experienced Superior to the stage where solitary molecules can be manipulated, that the primary experimental devices started to look.
‘It had been just a make any difference of finding up a book on mobile biology and starting to study. I'd come from a globe of extremely-substantial vacuums, cryostats and quantum phenomena, and now I was working at place temperature with molecular biology kits.
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and initial at any time research of your dynamics DNA supercoils and the discovery of supercoil hopping
Experimental section diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
You're a Christian. If you may make this kind of synthetic mobile, would you be a person phase nearer to God, or would the position of God have diminished fairly again?
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Dekker started his investigate on solitary carbon nanotubes in 1993 when he setup a new line of investigate to review electrical transport by solitary natural and organic molecules involving nanoelectrodes. In 1996 a breakthrough was realized with carbon nanotubes. This was obtained in the collaboration With all the team of Nobel laureate Richard Smalley. STM and nanolithography approaches had been utilized to show that these nanotubes are quantum wires at The one-molecule degree, with outstanding Bodily properties.
Tests pseudotopological and nontopological models for SMC-driven DNA loop extrusion from roadblock-traversal experiments
Several new phenomena were learned, and he and his analysis team proven a leading situation On this industry of investigation. Dekker and his research team found new physics of nanotubes and explored the feasibility of molecular electronics. In 1998, they had been the main to create a transistor based on an individual nanotube molecule.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij fulfilled enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever design and style in 2005. (nl)